[HTML][HTML] Hepatic Overexpression of Insulin-like Growth Factor-II in Adulthood Increases Basal and Insulin-stimulated Glucose Disposal in Conscious Mice (∗)
L Rossetti, N Barzilai, W Chen, T Harris, D Yang… - Journal of Biological …, 1996 - ASBMB
The physiological role of circulating insulin-like growth factor-II (IGF-II) in adult humans is
poorly understood. We recently generated an IGF-II transgenic murine model of persistent
IGF-II production (plasma IGF-II~ 30-fold increased above normal) through overexpression
of the transgene driven by the major urinary protein promoter (Rinderknecht, E., and
Humbel, RE (1978) J. Biol. Chem. 269, 13779-13784). To determine whether in vivo insulin
action is improved in these transgenic mice, we performed euglycemic insulin (18 …
poorly understood. We recently generated an IGF-II transgenic murine model of persistent
IGF-II production (plasma IGF-II~ 30-fold increased above normal) through overexpression
of the transgene driven by the major urinary protein promoter (Rinderknecht, E., and
Humbel, RE (1978) J. Biol. Chem. 269, 13779-13784). To determine whether in vivo insulin
action is improved in these transgenic mice, we performed euglycemic insulin (18 …