[HTML][HTML] An inhibitory fragment derived from protein kinase Cε prevents enhancement of nerve growth factor responses by ethanol and phorbol esters
B Hundle, T McMahon, J Dadgar, CH Chen… - Journal of Biological …, 1997 - ASBMB
We have studied nerve growth factor (NGF)-induced differentiation of PC12 cells to identify
PKC isozymes important for neuronal differentiation. Previous work showed that tumor-
promoting phorbol esters and ethanol enhance NGF-induced mitogen-activated protein
(MAP) kinase activation and neurite outgrowth by a PKC-dependent mechanism. Ethanol
also increases expression of PKCδ and PKCε, suggesting that one these isozymes
regulates responses to NGF. To examine this possibility, we established PC12 cell lines that …
PKC isozymes important for neuronal differentiation. Previous work showed that tumor-
promoting phorbol esters and ethanol enhance NGF-induced mitogen-activated protein
(MAP) kinase activation and neurite outgrowth by a PKC-dependent mechanism. Ethanol
also increases expression of PKCδ and PKCε, suggesting that one these isozymes
regulates responses to NGF. To examine this possibility, we established PC12 cell lines that …