[HTML][HTML] Pancreatic β-cell damage mediated by β-cell production of interleukin-1: a novel mechanism for virus-induced diabetes
MR Heitmeier, M Arnush, AL Scarim… - Journal of Biological …, 2001 - ASBMB
Viral infection is one environmental factor that may initiate β-cell damage during the
development of autoimmune diabetes. Formed during viral replication, double-stranded
RNA (dsRNA) activates the antiviral response in infected cells. In combination, synthetic
dsRNA (polyinosinic-polycytidylic acid, poly (IC)) and interferon (IFN)-γ stimulate inducible
nitric-oxide synthase (iNOS) expression, inhibit insulin secretion, and induce islet
degeneration. Interleukin-1 (IL-1) appears to mediate dsRNA+ IFN-γ-induced islet damage …
development of autoimmune diabetes. Formed during viral replication, double-stranded
RNA (dsRNA) activates the antiviral response in infected cells. In combination, synthetic
dsRNA (polyinosinic-polycytidylic acid, poly (IC)) and interferon (IFN)-γ stimulate inducible
nitric-oxide synthase (iNOS) expression, inhibit insulin secretion, and induce islet
degeneration. Interleukin-1 (IL-1) appears to mediate dsRNA+ IFN-γ-induced islet damage …