[HTML][HTML] Apoptosis-inducing membrane vesicles: a novel agent with unique properties
S Jodo, S Xiao, A Hohlbaum, D Strehlow… - Journal of Biological …, 2001 - ASBMB
The CD95 ligand (FasL) transmembrane protein is found on activated T cells and cells
outside the immune system. A well-known turnover process of membrane FasL is mediated
by matrix metalloproteinase, which generates soluble FasL (sFasL). Here, we demonstrate
that membrane FasL turnover occurs effectively through the release of membrane vesicles.
Quantitative analysis indicates that this process is as effective as sFasL release for FasL-3T3
cells but somewhat less effective for FasL-expressing T cells. The apoptosis-inducing …
outside the immune system. A well-known turnover process of membrane FasL is mediated
by matrix metalloproteinase, which generates soluble FasL (sFasL). Here, we demonstrate
that membrane FasL turnover occurs effectively through the release of membrane vesicles.
Quantitative analysis indicates that this process is as effective as sFasL release for FasL-3T3
cells but somewhat less effective for FasL-expressing T cells. The apoptosis-inducing …