Tissue-specific regulation of cytokine gene expression
IC Ho, JI Kim, SJ Szabo… - Cold Spring Harbor …, 1999 - symposium.cshlp.org
IC Ho, JI Kim, SJ Szabo, LH Glimcher
Cold Spring Harbor Symposia on Quantitative Biology, 1999•symposium.cshlp.orgWe and other investigators have isolated a number of transcription factors that appear to
control the tissue-specific expression of IL-4, and we have recently succeeded in identifying
a factor that directs the transcription of the IFN-γ gene. In this paper, we describe in more
detail the properties of two of these factors—the c-maf proto-oncogene and a novel T-box
family member that we have named T-bet—that we believe control the expression of the IL-4
and IFN-γ genes, respectively.
control the tissue-specific expression of IL-4, and we have recently succeeded in identifying
a factor that directs the transcription of the IFN-γ gene. In this paper, we describe in more
detail the properties of two of these factors—the c-maf proto-oncogene and a novel T-box
family member that we have named T-bet—that we believe control the expression of the IL-4
and IFN-γ genes, respectively.
We and other investigators have isolated a number of transcription factors that appear to control the tissue-specific expression of IL-4, and we have recently succeeded in identifying a factor that directs the transcription of the IFN-γ gene. In this paper, we describe in more detail the properties of two of these factors—the c-maf proto-oncogene and a novel T-box family member that we have named T-bet—that we believe control the expression of the IL-4 and IFN-γ genes, respectively.
symposium.cshlp.org