It has been shown in animal models that hepatocytes and cholangiocytes can derive from
bone marrow cells. We have investigated whether such a process occurs in humans.
Archival autopsy and biopsy liver specimens were obtained from 2 female recipients of
therapeutic bone marrow transplantations with male donors and from 4 male recipients of
orthotopic liver transplantations from female donors. Immunohistochemical staining with
monoclonal antibody CAM5. 2, specific for cytokeratins 8, 18, and 19, gave typical strong …