The role of oxygen free radicals in cisplatin-induced acute renal failure in rats

H Matsushima, K Yonemura, K Ohishi… - Journal of Laboratory and …, 1998 - Elsevier
We examined the role of oxygen free radicals in cisplatin-induced acute renal failure (ARF).
The intravenous injection of cisplatin (5 mg/kg body weight) induced an increase in serum
creatinine and tubular damage in the outer stripe of the outer medulla in rats. The renal
content of malondialdehyde (MDA) transiently increased. Treatment with the free radical
scavengers dimethylthiourea (DMTU) or lecithinized superoxide dismutase (L-SOD)
attenuated the increase in serum creatinine. The beneficial effect of DMTU, a hydroxyl …