Sodium arsenite induces heat shock protein-72 kilodalton expression in the lungs and protects rats against sepsis
SP Ribeiro, J Villar, GP Downey, JD Edelson… - Critical care …, 1994 - journals.lww.com
Objective: To examine the hypothesis that induction of heat shock proteins by a non-thermal
mechanism would confer protection against experimental sepsis. Design: Prospective, blind,
randomized, laboratory study. Setting: University research laboratory. Subjects: Sixty-two
adult male Sprague-Dawley rats (weight range 250 to 350 g). Interventions: Administration
of sodium arsenite or saline in an animal model of sepsis by cecal ligation and perforation.
Measurements and Main Results: Sixty-two rats were randomly divided into two groups …
mechanism would confer protection against experimental sepsis. Design: Prospective, blind,
randomized, laboratory study. Setting: University research laboratory. Subjects: Sixty-two
adult male Sprague-Dawley rats (weight range 250 to 350 g). Interventions: Administration
of sodium arsenite or saline in an animal model of sepsis by cecal ligation and perforation.
Measurements and Main Results: Sixty-two rats were randomly divided into two groups …