[HTML][HTML] Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid
Elevation of intracellular Ca 2+ in erythrocytes, platelets, and other cells initiates rapid
redistribution of plasma membrane phospholipids (PL) between inner and outer leaflets,
collapsing the normal asymmetric distribution. Consequently, phosphatidylserine and other
lipids normally sequestered to the inner leaflet become exposed at the cell surface. This Ca
2+-induced mobilization of phosphatidylserine to the surface of activated, injured, or
apoptotic cells confers a procoagulant property to the plasma membrane, which promotes …
redistribution of plasma membrane phospholipids (PL) between inner and outer leaflets,
collapsing the normal asymmetric distribution. Consequently, phosphatidylserine and other
lipids normally sequestered to the inner leaflet become exposed at the cell surface. This Ca
2+-induced mobilization of phosphatidylserine to the surface of activated, injured, or
apoptotic cells confers a procoagulant property to the plasma membrane, which promotes …