[HTML][HTML] Caveolins, a family of scaffolding proteins for organizing “preassembled signaling complexes” at the plasma membrane
T Okamoto, A Schlegel, PE Scherer… - Journal of Biological …, 1998 - ASBMB
Caveolae are vesicular invaginations of the plasma membrane. The chief structural proteins
of caveolae are the caveolins. Caveolins form a scaffold onto which many classes of
signaling molecules can assemble to generate preassembled signaling complexes. In
addition to concentrating these signal transducers within a distinct region of the plasma
membrane, caveolin binding may functionally regulate the activation state of caveolae-
associated signaling molecules. Because the responsibilities assigned to caveolae continue …
of caveolae are the caveolins. Caveolins form a scaffold onto which many classes of
signaling molecules can assemble to generate preassembled signaling complexes. In
addition to concentrating these signal transducers within a distinct region of the plasma
membrane, caveolin binding may functionally regulate the activation state of caveolae-
associated signaling molecules. Because the responsibilities assigned to caveolae continue …