[HTML][HTML] From brain to bile: evidence that conjugation and ω-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans
I Björkhem, U Andersson, E Ellis, G Alvelius… - Journal of Biological …, 2001 - ASBMB
The brain is the almost exclusive site of formation of 24S-hydroxycholesterol in man, and
there is a continuous flux of this oxysterol across the blood-brain barrier into the circulation.
The hepatic metabolism of 24S-hydroxycholesterol was studied here by three different
approaches: incubation of tritium-labeled 24S-hydroxycholesterol with human primary
hepatocytes, administration of tritium-labeled 24S-hydroxycholesterol to a human volunteer,
and quantitation of free and conjugated 24S-hydroxycholesterol and its neutral metabolites …
there is a continuous flux of this oxysterol across the blood-brain barrier into the circulation.
The hepatic metabolism of 24S-hydroxycholesterol was studied here by three different
approaches: incubation of tritium-labeled 24S-hydroxycholesterol with human primary
hepatocytes, administration of tritium-labeled 24S-hydroxycholesterol to a human volunteer,
and quantitation of free and conjugated 24S-hydroxycholesterol and its neutral metabolites …