[HTML][HTML] Novel members of the human oxysterol-binding protein family bind phospholipids and regulate vesicle transport
Y Xu, Y Liu, ND Ridgway, CR McMaster - Journal of Biological Chemistry, 2001 - ASBMB
Oxysterol-binding proteins (OSBPs) are a family of eukaryotic intracellular lipid receptors.
Mammalian OSBP1 binds oxygenated derivatives of cholesterol and mediates sterol and
phospholipid synthesis through as yet poorly undefined mechanisms. The precise cellular
roles for the remaining members of the oxysterol-binding protein family remain to be
elucidated. In yeast, a family of OSBPs has been identified based on primary sequence
similarity to the ligand binding domain of mammalian OSBP1. Yeast Kes1p, an oxysterol …
Mammalian OSBP1 binds oxygenated derivatives of cholesterol and mediates sterol and
phospholipid synthesis through as yet poorly undefined mechanisms. The precise cellular
roles for the remaining members of the oxysterol-binding protein family remain to be
elucidated. In yeast, a family of OSBPs has been identified based on primary sequence
similarity to the ligand binding domain of mammalian OSBP1. Yeast Kes1p, an oxysterol …
