[HTML][HTML] Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface
L Bretillon, D Lütjohann, L Ståhle, T Widhe, L Bindl… - Journal of lipid …, 2000 - ASBMB
We have previously presented evidence that most of the 24S-hydroxycholesterol present in
the circulation originates from the brain and that most of the elimination of this oxysterol
occurs in the liver. Plasma 24S-hydroxycholesterol levels decline by a factor of about 5
during the first decades of life. The concentration of the enzyme cholesterol 24S-hydroxylase
in the brain is, however, about constant from the first year of life, and reduced enzyme levels
thus cannot explain the decreasing plasma levels during infancy. In the present work we …
the circulation originates from the brain and that most of the elimination of this oxysterol
occurs in the liver. Plasma 24S-hydroxycholesterol levels decline by a factor of about 5
during the first decades of life. The concentration of the enzyme cholesterol 24S-hydroxylase
in the brain is, however, about constant from the first year of life, and reduced enzyme levels
thus cannot explain the decreasing plasma levels during infancy. In the present work we …