[HTML][HTML] Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts)
X Xu, R Bittman, G Duportail, D Heissler… - Journal of Biological …, 2001 - ASBMB
Ordered lipid domains enriched in sphingolipids and cholesterol (lipid rafts) have been
implicated in numerous functions in biological membranes. We recently found that lipid
domain/raft formation is dependent on the sterol component having a structure that allows
tight packing with lipids having saturated acyl chains (Xu, X., and London, E.(2000)
Biochemistry 39, 844–849). In this study, the domain-promoting activities of variousnatural
sterols were compared with that of cholesterol using both fluorescence quenching and …
implicated in numerous functions in biological membranes. We recently found that lipid
domain/raft formation is dependent on the sterol component having a structure that allows
tight packing with lipids having saturated acyl chains (Xu, X., and London, E.(2000)
Biochemistry 39, 844–849). In this study, the domain-promoting activities of variousnatural
sterols were compared with that of cholesterol using both fluorescence quenching and …