[HTML][HTML] Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8
KE Berge, K Von Bergmann, D Lutjohann… - Journal of lipid …, 2002 - ASBMB
The plasma concentrations of cholesterol precursor sterols and plant sterols vary over a 5-to
10-fold range among normolipidemic individuals, and provide indices of the relative rates of
cholesterol synthesis and fractional absorption. In the present study, we examined the
relative contributions of genetic and environmental factors to variation in the plasma
concentrations and sterol-cholesterol ratios of five noncholesterol sterols, including the 5α-
saturated derivative of cholesterol (cholestanol), two precursors in the cholesterol …
10-fold range among normolipidemic individuals, and provide indices of the relative rates of
cholesterol synthesis and fractional absorption. In the present study, we examined the
relative contributions of genetic and environmental factors to variation in the plasma
concentrations and sterol-cholesterol ratios of five noncholesterol sterols, including the 5α-
saturated derivative of cholesterol (cholestanol), two precursors in the cholesterol …