Prostaglandin E2 regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1β-treated …
WH Faour, Y He, QW He, M de Ladurantaye… - Journal of Biological …, 2001 - ASBMB
The p38 MAPK mediates transcriptional and post-transcriptional control of cyclooxygenase-
2 (COX-2) mRNA following interleukin-1 (IL-1)/lipopolysaccharide cellular activation. We
explored a positive feedback, prostaglandin E 2 (PGE 2)-dependent stabilization of COX-2
mRNA mediated by the p38 MAPK cascade in IL-1β-stimulated human synovial fibroblasts.
We observed a rapid (5 min), massive (> 30-fold), and sustained (> 48 h) increase in COX-2
mRNA, protein, and PGE 2 release following a recombinant human (rh) IL-1β signal that was …
2 (COX-2) mRNA following interleukin-1 (IL-1)/lipopolysaccharide cellular activation. We
explored a positive feedback, prostaglandin E 2 (PGE 2)-dependent stabilization of COX-2
mRNA mediated by the p38 MAPK cascade in IL-1β-stimulated human synovial fibroblasts.
We observed a rapid (5 min), massive (> 30-fold), and sustained (> 48 h) increase in COX-2
mRNA, protein, and PGE 2 release following a recombinant human (rh) IL-1β signal that was …
