[HTML][HTML] Matrix metalloproteinase-2 is an interstitial collagenase: inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type i collagen …
RT Aimes, JP Quigley - Journal of Biological Chemistry, 1995 - ASBMB
The 72-kDa gelatinase/type IV collagenase (MMP-2) is a member of the matrix
metalloproteinase (MMP) family of enzymes. This enzyme is known to cleave type IV
collagen as well as degrade denatured collagens. However, native interstitial collagens are
reportedly resistant to MMP-2 and are thought to be susceptible only to the interstitial
collagenases MMP-1 and MMP-8. In this study we report that both human and chicken MMP-
2, free of tissue inhibitors of metalloproteinases (TIMPs) are capable of cleaving soluble …
metalloproteinase (MMP) family of enzymes. This enzyme is known to cleave type IV
collagen as well as degrade denatured collagens. However, native interstitial collagens are
reportedly resistant to MMP-2 and are thought to be susceptible only to the interstitial
collagenases MMP-1 and MMP-8. In this study we report that both human and chicken MMP-
2, free of tissue inhibitors of metalloproteinases (TIMPs) are capable of cleaving soluble …