[HTML][HTML] Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice
C Miyaura, M Inada, T Suzawa, Y Sugimoto… - Journal of Biological …, 2000 - ASBMB
Prostaglandin E 2 (PGE 2) acts as a potent stimulator of bone resorption. In this study, we
first clarified in normal ddy mice the involvement of protein kinase A and induction of matrix
metalloproteinases (MMPs) in PGE 2-induced bone resorption, and then identified PGE
receptor subtype (s) mediating this PGE 2 action using mice lacking each subtype (EP1,
EP2, EP3, and EP4) of PGE receptor. In calvarial culture obtained from normal ddy mice,
both PGE 2 and dibutyryl cyclic AMP (Bt 2 cAMP) stimulated bone resorption and induced …
first clarified in normal ddy mice the involvement of protein kinase A and induction of matrix
metalloproteinases (MMPs) in PGE 2-induced bone resorption, and then identified PGE
receptor subtype (s) mediating this PGE 2 action using mice lacking each subtype (EP1,
EP2, EP3, and EP4) of PGE receptor. In calvarial culture obtained from normal ddy mice,
both PGE 2 and dibutyryl cyclic AMP (Bt 2 cAMP) stimulated bone resorption and induced …