Influence of bile salts on molecular interactions between sphingomyelin and cholesterol: relevance to bile formation and stability
KJ van Erpecum, MC Carey - Biochimica et Biophysica Acta (BBA)-Lipids …, 1997 - Elsevier
Bile salts enhance secretion of cholesterol into bile and its subsequent solubilization with
phosphatidylcholine in mixed micelles. Sphingomyelin, a major structural lipid of the
hepatocyte canalicular membrane, and disaturated phosphatidylcholines are known to
impede nucleation of solid cholesterol crystals in supersaturated model systems. To
understand these effects physico-chemically, we compared the influence of bile salts on
interactions of cholesterol with natural sphingomyelins, as well as with dipalmitoyl and egg …
phosphatidylcholine in mixed micelles. Sphingomyelin, a major structural lipid of the
hepatocyte canalicular membrane, and disaturated phosphatidylcholines are known to
impede nucleation of solid cholesterol crystals in supersaturated model systems. To
understand these effects physico-chemically, we compared the influence of bile salts on
interactions of cholesterol with natural sphingomyelins, as well as with dipalmitoyl and egg …