The LXRs: a new class of oxysterol receptors
DJ Peet, BA Janowski, DJ Mangelsdorf - Current opinion in genetics & …, 1998 - Elsevier
DJ Peet, BA Janowski, DJ Mangelsdorf
Current opinion in genetics & development, 1998•ElsevierThe liver X receptors (LXRs) are a family of transcription factors that were first identified as
orphan members of the nuclear receptor superfamily. The identification of a specific class of
oxidized derivatives of cholesterol as ligands for the LXRs has been crucial to helping
understand the function of these receptors in vivo and first suggested their role in the
regulation of lipid metabolism. Confirmation of this role has come from the recent analysis of
LXR-deficient mice, which has demonstrated the essential function of one of these receptors …
orphan members of the nuclear receptor superfamily. The identification of a specific class of
oxidized derivatives of cholesterol as ligands for the LXRs has been crucial to helping
understand the function of these receptors in vivo and first suggested their role in the
regulation of lipid metabolism. Confirmation of this role has come from the recent analysis of
LXR-deficient mice, which has demonstrated the essential function of one of these receptors …
The liver X receptors (LXRs) are a family of transcription factors that were first identified as orphan members of the nuclear receptor superfamily. The identification of a specific class of oxidized derivatives of cholesterol as ligands for the LXRs has been crucial to helping understand the function of these receptors in vivo and first suggested their role in the regulation of lipid metabolism. Confirmation of this role has come from the recent analysis of LXR-deficient mice, which has demonstrated the essential function of one of these receptors in the liver as a major sensor of dietary cholesterol.
Elsevier