Effective diminution of amniotic prostaglandin production by selective inhibitors of cyclooxygenase type 2
Y Sadovsky, DM Nelson, LJ Muglia, GA Gross… - American journal of …, 2000 - Elsevier
Objective: Cyclooxygenase inhibitors are effective tocolytic agents, but significant adverse
effects limit their use. We hypothesized that selective inhibitors of the isozyme
cyclooxygenase 2 would effectively diminish labor-associated prostaglandin production.
Study Design: We analyzed cyclooxygenase type 1 and 2 expression in amnion, chorion,
decidua, and myometrium from laboring or nonlaboring women and tested the efficacy of
selective cyclooxygenase 2 inhibition in diminishing prostaglandin production. Results: The …
effects limit their use. We hypothesized that selective inhibitors of the isozyme
cyclooxygenase 2 would effectively diminish labor-associated prostaglandin production.
Study Design: We analyzed cyclooxygenase type 1 and 2 expression in amnion, chorion,
decidua, and myometrium from laboring or nonlaboring women and tested the efficacy of
selective cyclooxygenase 2 inhibition in diminishing prostaglandin production. Results: The …