[HTML][HTML] Functional analysis of the domain structure of tumor necrosis factor-α converting enzyme
P Reddy, JL Slack, R Davis, DP Cerretti… - Journal of Biological …, 2000 - ASBMB
Many membrane-bound proteins, including cytokines, receptors, and growth factors, are
proteolytically cleaved to release a soluble form of their extracellular domain. The tumor
necrosis factor (TNF)-α converting enzyme (TACE/ADAM-17) is a transmembrane
metalloproteinase responsible for the proteolytic release or" shedding" of several cell-
surface proteins, including TNF and p75 TNFR. We established a TACE-reconstitution
system using TACE-deficient cells co-transfected with TACE and substrate cDNAs to study …
proteolytically cleaved to release a soluble form of their extracellular domain. The tumor
necrosis factor (TNF)-α converting enzyme (TACE/ADAM-17) is a transmembrane
metalloproteinase responsible for the proteolytic release or" shedding" of several cell-
surface proteins, including TNF and p75 TNFR. We established a TACE-reconstitution
system using TACE-deficient cells co-transfected with TACE and substrate cDNAs to study …