[HTML][HTML] Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia …
P Holden, RS Meadows, KL Chapman… - Journal of Biological …, 2001 - ASBMB
Cartilage oligomeric matrix protein (COMP) and type IX collagen are key structural
components of the cartilage extracellular matrix and have important roles in tissue
development and homeostasis. Mutations in the genes encoding these glycoproteins result
in two related human bone dysplasias, pseudoachondroplasia and multiple epiphyseal
dysplasia, which together comprise a" bone dysplasia family." It has been proposed that
these diseases have a similar pathophysiology, which is highlighted by the fact that …
components of the cartilage extracellular matrix and have important roles in tissue
development and homeostasis. Mutations in the genes encoding these glycoproteins result
in two related human bone dysplasias, pseudoachondroplasia and multiple epiphyseal
dysplasia, which together comprise a" bone dysplasia family." It has been proposed that
these diseases have a similar pathophysiology, which is highlighted by the fact that …