Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD
Background A central feature in the pathogenesis of COPD is the inflammation coexisting
with an abnormal protease/antiprotease balance. However, the possible role of different
serine and metalloproteinases remains controversial. Patients and measurements We
examined the expression of gelatinases A and B (matrix metalloproteinase [MMP]-2 and
MMP-9); collagenases 1, 2, and 3 (MMP-1, MMP-8, and MMP-13); as well as the presence of
apoptosis in lung tissues of 10 COPD patients and 5 control subjects. In addition, gelatinase …
with an abnormal protease/antiprotease balance. However, the possible role of different
serine and metalloproteinases remains controversial. Patients and measurements We
examined the expression of gelatinases A and B (matrix metalloproteinase [MMP]-2 and
MMP-9); collagenases 1, 2, and 3 (MMP-1, MMP-8, and MMP-13); as well as the presence of
apoptosis in lung tissues of 10 COPD patients and 5 control subjects. In addition, gelatinase …