Middle-sized molecule fractions isolated from uremic ultrafiltrate and normal urine inhibit ingestive behavior in the rat.
B Anderstam, AH Mamoun, P Södersten… - Journal of the …, 1996 - journals.lww.com
Uremic patients with suppressed food intake may regain appetite soon after starting dialysis,
presumably because of the removal of one or more toxic factors that suppress appetite. To
investigate this matter, this study used a new experimental model in free-moving, unstressed
male Wistar rats (300 to 350 g) with feeding catheters channeled from the top of the skull to
the oral cavity. When the rats recovered from surgery, they were tested under standardized
conditions by being given an intraoral infusion (1 mL/min) of a 1 M sucrose solution or a 97 …
presumably because of the removal of one or more toxic factors that suppress appetite. To
investigate this matter, this study used a new experimental model in free-moving, unstressed
male Wistar rats (300 to 350 g) with feeding catheters channeled from the top of the skull to
the oral cavity. When the rats recovered from surgery, they were tested under standardized
conditions by being given an intraoral infusion (1 mL/min) of a 1 M sucrose solution or a 97 …