Recent studies have shown that systemic injection of anti-VEGF antibody into tumor-bearing
mice results in decreases in tumor vascular permeability, vessel diameters, and tumor
regression. Using a similar animal model, we have applied anti-VEGF antibody directly to
the tumor tissue growing in transparent window chambers in SCID mice. Similar to the
results obtained with systemic injection, vascular permeability was greatly reduced, but the
response was reached at much lower concentrations with local application. Implications of …