[HTML][HTML] Disruption of the A3 adenosine receptor gene in mice and its effect on stimulated inflammatory cells
CA Salvatore, SL Tilley, AM Latour, DS Fletcher… - Journal of Biological …, 2000 - ASBMB
The A 3 adenosine receptor (A3AR) is one of four receptor subtypes for adenosine and is
expressed in a broad spectrum of tissues. In order to study the function of A3AR, a mouse
line carrying a mutant A 3 allele was generated. Mice homozygous for targeted disruption of
the A3AR gene, A3AR−/−, are fertile and visually and histologically indistinguishable from
wild type mice. The lack of a functional receptor in the A3AR−/− mice was confirmed by
molecular and pharmacological analyses. The absence of A3AR protein expression in the …
expressed in a broad spectrum of tissues. In order to study the function of A3AR, a mouse
line carrying a mutant A 3 allele was generated. Mice homozygous for targeted disruption of
the A3AR gene, A3AR−/−, are fertile and visually and histologically indistinguishable from
wild type mice. The lack of a functional receptor in the A3AR−/− mice was confirmed by
molecular and pharmacological analyses. The absence of A3AR protein expression in the …