Primary structure and functional expression of a mouse inward rectifier potassium channel
Y Kubo, TJ Baldwin, Y Nung Jan, LY Jan - Nature, 1993 - nature.com
Y Kubo, TJ Baldwin, Y Nung Jan, LY Jan
Nature, 1993•nature.comA complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a
mouse macrophage cell line by expression cloning. This channel conducts inward K+
current below the K+ equilibrium potential but passes little outward K+ current. The IRK1
channel contains only two putative transmembrane segments per subunit and corresponds
to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-
regulated K+ channel show extensive sequence similarity and constitute a new superfamily.
mouse macrophage cell line by expression cloning. This channel conducts inward K+
current below the K+ equilibrium potential but passes little outward K+ current. The IRK1
channel contains only two putative transmembrane segments per subunit and corresponds
to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-
regulated K+ channel show extensive sequence similarity and constitute a new superfamily.
Abstract
A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.
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