[HTML][HTML] Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain
AS Hackam, AS Yassa, M Metzler, CA Gutekunst… - Journal of Biological …, 2000 - ASBMB
Huntington disease is a devastating neurodegenerative disease caused by the expansion of
a polymorphic glutamine tract in huntingtin. The huntingtin interacting protein (HIP-1) was
identified by its altered interaction with mutant huntingtin. However, the function of HIP-1 was
not known. In this study, we identify HIP-1 as a proapoptotic protein. Overexpression of HIP-
1 resulted in rapid caspase 3-dependent cell death. Bioinformatics analyses identified a
novel domain in HIP-1 with homology to death effector domains (DEDs) present in proteins …
a polymorphic glutamine tract in huntingtin. The huntingtin interacting protein (HIP-1) was
identified by its altered interaction with mutant huntingtin. However, the function of HIP-1 was
not known. In this study, we identify HIP-1 as a proapoptotic protein. Overexpression of HIP-
1 resulted in rapid caspase 3-dependent cell death. Bioinformatics analyses identified a
novel domain in HIP-1 with homology to death effector domains (DEDs) present in proteins …