Defects in sensory nerve numbers and growth in mutant Kit and Steel mice
S Lourenssen, B Motro, A Bernstein, J Diamond - Neuroreport, 2000 - journals.lww.com
The roles in the nervous system of the receptor tyrosine kinase Kit and its ligand, Steel
factor, are unclear. We have now found first, that sensory nerve populations are reduced in
mutant Kit and Steel mice, implicating Steel–Kit interactions in neuronal development.
Second, sensory axonal regeneration (which occurs independently of nerve growth factor, or
NGF) is impaired, while collateral sprouting (NGF dependent) is normal. Therefore, there is a
selective involvement of Kit signal transduction pathways in nerve growth; supporting this, in …
factor, are unclear. We have now found first, that sensory nerve populations are reduced in
mutant Kit and Steel mice, implicating Steel–Kit interactions in neuronal development.
Second, sensory axonal regeneration (which occurs independently of nerve growth factor, or
NGF) is impaired, while collateral sprouting (NGF dependent) is normal. Therefore, there is a
selective involvement of Kit signal transduction pathways in nerve growth; supporting this, in …