Mouse loci for malaria-induced mortality and the control of parasitaemia.
SJ Foote, RA Burt, TM Baldwin, A Presente… - 1997 - cabidigitallibrary.org
1997•cabidigitallibrary.org
Two mouse strains (C3H/He and SJL) susceptible to Plasmodium chabaudi-induced malaria
were crossed with the resistant strain C57BL/6 and bred to the F2 generation. All F1 animals
survived infection with P. chabaudi adami, which indicated that resistance was dominant.
The mortality for F2 progeny was 11-15%. The entire genomes of all the mice were scanned
using single-strand length polymorphism markers to identify loci conferring resistance. Two
loci were identified, one on chromosome 9 and one on chromosome 8, which were named …
were crossed with the resistant strain C57BL/6 and bred to the F2 generation. All F1 animals
survived infection with P. chabaudi adami, which indicated that resistance was dominant.
The mortality for F2 progeny was 11-15%. The entire genomes of all the mice were scanned
using single-strand length polymorphism markers to identify loci conferring resistance. Two
loci were identified, one on chromosome 9 and one on chromosome 8, which were named …
Abstract
Two mouse strains (C3H/He and SJL) susceptible to Plasmodium chabaudi-induced malaria were crossed with the resistant strain C57BL/6 and bred to the F2 generation. All F1 animals survived infection with P. chabaudi adami, which indicated that resistance was dominant. The mortality for F2 progeny was 11-15%. The entire genomes of all the mice were scanned using single-strand length polymorphism markers to identify loci conferring resistance. Two loci were identified, one on chromosome 9 and one on chromosome 8, which were named P. chabaudi resistance loci -1 and -2 (char1 and char2) respectively. Candidate genes at these loci were identified including haptoglobin, transferrin, 2 retinol-binding proteins and an erythrocyte surface antigen.
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