Th1/Th2 effector choice in parasitic infection: decision making by committee
D Jankovic, A Sher, G Yap - Current opinion in immunology, 2001 - Elsevier
D Jankovic, A Sher, G Yap
Current opinion in immunology, 2001•ElsevierParasitic infections frequently result in highly polarized CD4+ T cell responses characterized
by dominant Th1 or Th2 cytokine production profiles. Although previously thought to be
strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data
indicate that this polarization may be primarily decided instead by a series of different factors
intrinsic to the pathogen–antigen-presenting-cell interaction that influence T cell priming.
by dominant Th1 or Th2 cytokine production profiles. Although previously thought to be
strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data
indicate that this polarization may be primarily decided instead by a series of different factors
intrinsic to the pathogen–antigen-presenting-cell interaction that influence T cell priming.
Parasitic infections frequently result in highly polarized CD4+ T cell responses characterized by dominant Th1 or Th2 cytokine production profiles. Although previously thought to be strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data indicate that this polarization may be primarily decided instead by a series of different factors intrinsic to the pathogen–antigen-presenting-cell interaction that influence T cell priming.
Elsevier