Because proliferation of mesangial cells is a hallmark of glomerular diseases,
understanding the regulatory mechanism of mesangial proliferation is important for the
treatment. Warfarin has long been used to treat glomerular diseases, although its
mechanism of effect on mesangial proliferation has remained unknown. Therefore, this study
was conducted to examine whether warfarin can inhibit mouse mesangial cell proliferation
by focusing on Gas6, which has been shown to be activated by vitamin K-dependent γ …