Suppression of TNF-α-induced apoptosis by NF-κB
Tumor necrosis factor α (TNF-α) signaling gives rise to a number of events, including
activation of transcription factor NF-κB and programmed cell death (apoptosis). Previous
studies of TNF-α signaling have suggested that these two events occur independently. The
sensitivity and kinetics of TNF-α-induced apoptosis are shown to be enhanced in a number
of cell types expressing a dominant-negative IκBα (IκBαM). These findings suggest that a
negative feedback mechanism results from TNF-α signaling in which NF-κB activation …
activation of transcription factor NF-κB and programmed cell death (apoptosis). Previous
studies of TNF-α signaling have suggested that these two events occur independently. The
sensitivity and kinetics of TNF-α-induced apoptosis are shown to be enhanced in a number
of cell types expressing a dominant-negative IκBα (IκBαM). These findings suggest that a
negative feedback mechanism results from TNF-α signaling in which NF-κB activation …
Tumor necrosis factor α (TNF-α) signaling gives rise to a number of events, including activation of transcription factor NF-κB and programmed cell death (apoptosis). Previous studies of TNF-α signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-α-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IκBα (IκBαM). These findings suggest that a negative feedback mechanism results from TNF-α signaling in which NF-κB activation suppresses the signals for cell death.
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