Inhibition of NFκB in activated rat hepatic stellate cells by proteasome inhibitors and an IκB super-repressor
The hepatic stellate cell (HSC), following a fibrogenic stimulus, is transformed from a
quiescent to an activated cell. Cytokines induce NFκB activity in activated but not in
quiescent HSCs with subsequent expression of NFκB-responsive genes, such as
intercellular adhesion molecule (ICAM)-1 and interleukin (IL)-6. We investigated the effect of
proteasome inhibitors and an IκB super-repressor on the cytokine mediated activation of
NFκB, ICAM-1, and IL-6 in activated HSCs. Culture-activated HSCs were stimulated with IL …
quiescent to an activated cell. Cytokines induce NFκB activity in activated but not in
quiescent HSCs with subsequent expression of NFκB-responsive genes, such as
intercellular adhesion molecule (ICAM)-1 and interleukin (IL)-6. We investigated the effect of
proteasome inhibitors and an IκB super-repressor on the cytokine mediated activation of
NFκB, ICAM-1, and IL-6 in activated HSCs. Culture-activated HSCs were stimulated with IL …