Lethal hepatic apoptosis mediated by tumor necrosis factor receptor, unlike Fas-mediated apoptosis, requires hepatocyte sensitization in mice
M Nagaki, A Sugiyama, Y Osawa, T Naiki… - Journal of …, 1999 - Elsevier
Background/Aims: Tumor necrosis factor α (TNF-α) and Fas ligand are apoptotic cell-death
mediators that act by binding to their responsive receptors. The aims of this study were to
assess the differences between liver cell deaths induced by TNF-α and anti-Fas antibody,
and to investigate the mechanism by which GalN sensitizes the hepatocyte to injury by TNF-
α. Methods: TNF-α or anti-Fas antibody was injected into BALB/c mice sensitized or
unsensitized by D-galactosamine (GalN). Liver injury was assessed biochemically and …
mediators that act by binding to their responsive receptors. The aims of this study were to
assess the differences between liver cell deaths induced by TNF-α and anti-Fas antibody,
and to investigate the mechanism by which GalN sensitizes the hepatocyte to injury by TNF-
α. Methods: TNF-α or anti-Fas antibody was injected into BALB/c mice sensitized or
unsensitized by D-galactosamine (GalN). Liver injury was assessed biochemically and …