[HTML][HTML] Lipid-dependent targeting of G proteins into rafts
S Moffett, DA Brown, ME Linder - Journal of Biological Chemistry, 2000 - ASBMB
Domains rich in sphingolipids and cholesterol, or rafts, may organize signal transduction
complexes at the plasma membrane. Raft lipids are believed to exist in a state similar to the
liquid-ordered phase. It has been proposed that proteins with a high affinity for an ordered
lipid environment will preferentially partition into rafts (Melkonian, KA, Ostermeyer, AG,
Chen, JZ, Roth, MG, and Brown, DA (1999) J. Biol. Chem. 274, 3910–3917). We
investigated the possibility that lipid-lipid interactions between lipid-modified proteins and …
complexes at the plasma membrane. Raft lipids are believed to exist in a state similar to the
liquid-ordered phase. It has been proposed that proteins with a high affinity for an ordered
lipid environment will preferentially partition into rafts (Melkonian, KA, Ostermeyer, AG,
Chen, JZ, Roth, MG, and Brown, DA (1999) J. Biol. Chem. 274, 3910–3917). We
investigated the possibility that lipid-lipid interactions between lipid-modified proteins and …