[HTML][HTML] Retinoic Acid-mediated Activation of the MouseRenin Enhancer

Q Shi, KW Gross, CD Sigmund - Journal of Biological Chemistry, 2001 - ASBMB
Previous studies demonstrate that the mouserenin gene is regulated by a complex enhancer
of transcription located 2.6 kilobases upstream of the transcription start site which is under
both positive and negative influence. We demonstrate herein that a positive regulatory
element (Eb) is repeated 10 bp upstream (Ec), and both are required for baseline activity of
the enhancer. The Eb and Ec core sequences are identical to the consensus sequence for
the nuclear hormone receptor superfamily of transcription factors, and transcriptional activity …