A toxoid vaccine for pertussis as well as diphtheria? Lessons to be relearned

R Schneerson, JB Robbins, J Taranger, T Lagergard… - The Lancet, 1996 - thelancet.com
R Schneerson, JB Robbins, J Taranger, T Lagergard, B Trollfors
The Lancet, 1996thelancet.com
Diphtheria is not highly contagious and—before the advent of toxoid vaccines—about 10%
of the population, mostly children, contracted diphtheria. 2–4 Patients with diphtheria, many
with only a sore throat, comprised the most common source of tox+ C diphtheriae. By
contrast, pertussis is highly contagious and—before mass vaccination programmes—most
people who experienced this disease did so in childhood. This difference is probably due to
the severe coughing that favours transmission of B pertussis.
Diphtheria is not highly contagious and—before the advent of toxoid vaccines—about 10% of the population, mostly children, contracted diphtheria. 2–4 Patients with diphtheria, many with only a sore throat, comprised the most common source of tox+ C diphtheriae. By contrast, pertussis is highly contagious and—before mass vaccination programmes—most people who experienced this disease did so in childhood. This difference is probably due to the severe coughing that favours transmission of B pertussis.
thelancet.com