Non-toxigenic derivatives of the Ames strain of Bacillus anthracis are fully virulent for mice: role of plasmid pX02 and chromosome in strain-dependent virulence
SL Welkos, NJ Vietri, PH Gibbs - Microbial pathogenesis, 1993 - Elsevier
The toxin-encoding plasmid pX01 and capsule-associated plasmid pX02 are required for full
virulence of Bacillus anthracis in some animals. However, the non-toxigenic pX01-cured
derivatives of certain anthrax strains are not completely attenuated for mice, and their
virulence is strain-dependent. The strain-related differences were partially associated with
plasmid pX02 as demonstrated by pX02 transductants of the attenuated vaccine strain
UM23-1 cured of pX01, To determine the virulence of non-toxigenic variants of virulent …
virulence of Bacillus anthracis in some animals. However, the non-toxigenic pX01-cured
derivatives of certain anthrax strains are not completely attenuated for mice, and their
virulence is strain-dependent. The strain-related differences were partially associated with
plasmid pX02 as demonstrated by pX02 transductants of the attenuated vaccine strain
UM23-1 cured of pX01, To determine the virulence of non-toxigenic variants of virulent …