Effect of zanamivir on duration and resolution of influenza symptoms

AS Monto, AB Moult, SJ Sharp - Clinical therapeutics, 2000 - Elsevier
Background: Zanamivir is a neuraminidase inhibitor, the first of a new class of drugs with
potent, specific antiviral activity against influenza A and B. Administration by inhalation
results in direct delivery to the respiratory tract, the principal site of viral replication.
Objective: This study was undertaken to determine the effectiveness of zanamivir on
duration and resolution of influenza symptoms. Methods: Using a method similar to that
employed in amantadine treatment studies to obtain supporting evidence of efficacy for US …