Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial

JJ Treanor, FG Hayden, PS Vrooman, R Barbarash… - Jama, 2000 - jamanetwork.com
ContextPrevious studies have shown oseltamivir, a neuraminidase inhibitor, to be effective
in preventing influenza and treating experimental influenza. ObjectiveTo evaluate the
efficacy and safety of oseltamivir in the treatment of naturally acquired influenza infection.
DesignRandomized, placebo-controlled, double-blind study conducted January through
March 1998. SettingSixty primary care and university health centers throughout the United
States. ParticipantsA total of 629 healthy nonimmunized adults aged 18 to 65 years with …