Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis
RM McCarron, RJ Fallis, DE McFarlin - Journal of neuroimmunology, 1990 - Elsevier
In order to assess T cell antigen specificities and class II restriction requirements during the
course of chronic relapsing experimental allergic encephalomyelitis (CREAE),(SJL× PL) F1
mice were used as a model. EAE can be passively transferred in these mice by F1 T cells
incubated with Ia-positive antigen-presenting cells (APC) from either parent SJL (H-2 s) or
PL (H-2 u) and MBP fragments 89–169 or 1–37, respectively. T cells purified from F1 mice
immunized with MBP fragment 1–37 were positively selected for IA u-supported proliferation …
course of chronic relapsing experimental allergic encephalomyelitis (CREAE),(SJL× PL) F1
mice were used as a model. EAE can be passively transferred in these mice by F1 T cells
incubated with Ia-positive antigen-presenting cells (APC) from either parent SJL (H-2 s) or
PL (H-2 u) and MBP fragments 89–169 or 1–37, respectively. T cells purified from F1 mice
immunized with MBP fragment 1–37 were positively selected for IA u-supported proliferation …