T-cells specific for soluble recombinant oligodendrocyte-specific protein induce severe clinical experimental autoimmune encephalomyelitis in H-2b and H-2s mice
MC Zhong, L Cohen, A Meshorer, NK de Rosbo… - Journal of …, 2000 - Elsevier
To investigate the immunogenicity and encephalitogenicity of oligodendrocyte-specific
protein (OSP), recombinant soluble mouse OSP (smOSP) was produced from a synthetic
gene engineered to lack the sequences coding for the hydrophobic transmembrane
domains of the native molecule. SmOSP was immunogenic and encephalitogenic for SJL/J,
C3H. SW and C57BL/6J mice, but not PL/J or BALB/c mice. SmOSP-specific T-cells from
SJL/J, C3H. SW and C57BL/6J mice induced severe chronic clinical experimental …
protein (OSP), recombinant soluble mouse OSP (smOSP) was produced from a synthetic
gene engineered to lack the sequences coding for the hydrophobic transmembrane
domains of the native molecule. SmOSP was immunogenic and encephalitogenic for SJL/J,
C3H. SW and C57BL/6J mice, but not PL/J or BALB/c mice. SmOSP-specific T-cells from
SJL/J, C3H. SW and C57BL/6J mice induced severe chronic clinical experimental …