T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects
JL Trotter, CM Pelfrey, AL Trotter, JA Selvidge… - Journal of …, 1998 - Elsevier
Myelin proteolipid protein (PLP) is a prime candidate autoantigen for multiple sclerosis. In
order to define potential immunodominant epitopes, T cell lines (TCL) from the peripheral
blood of HLA-DR 15 (2) MS patients were established which responded to the intact
molecule of PLP. These TCL were then tested in individual proliferation assays with a variety
of PLP peptides spanning most of the PLP molecule. Multiple peptides were recognized by
TCL from the MS population, with more than one peptide often recognized by lines from the …
order to define potential immunodominant epitopes, T cell lines (TCL) from the peripheral
blood of HLA-DR 15 (2) MS patients were established which responded to the intact
molecule of PLP. These TCL were then tested in individual proliferation assays with a variety
of PLP peptides spanning most of the PLP molecule. Multiple peptides were recognized by
TCL from the MS population, with more than one peptide often recognized by lines from the …