Effects of celecoxib and naproxen on renal function in the elderly
A Whelton, G Schulman, C Wallemark… - Archives of internal …, 2000 - jamanetwork.com
Objective To compare the effects of celecoxib, a cyclooxygenase 2–specific inhibitor, with
the nonspecific cyclooxygenase 1 and 2 inhibitor naproxen on renal function in 29 healthy
elderly subjects in a single-blind, randomized, crossover study. Methods Subjects received
either celecoxib, 200 mg twice daily, for 5 days followed by celecoxib, 400 mg twice daily, for
the next 5 days, or they received naproxen, 500 mg twice daily, for 10 days. After a 7-day
washout, subjects were crossed over to receive the other regimen. Results After the first …
the nonspecific cyclooxygenase 1 and 2 inhibitor naproxen on renal function in 29 healthy
elderly subjects in a single-blind, randomized, crossover study. Methods Subjects received
either celecoxib, 200 mg twice daily, for 5 days followed by celecoxib, 400 mg twice daily, for
the next 5 days, or they received naproxen, 500 mg twice daily, for 10 days. After a 7-day
washout, subjects were crossed over to receive the other regimen. Results After the first …