Interactions of exendin-(9–39) with the effects of glucagon-like peptide-1-(7–36) amide and of exendin-4 on arterial blood pressure and heart rate in rats

JM Barragan, RE Rodríguez, J Eng, E Blázquez - Regulatory peptides, 1996 - Elsevier
This study was designed to determine the interactions of peptide exendin-(9–39) with the
effect of glucagon-like peptide-1-(7–36)(GLP-1 (7–36)) amide and of exendin-4 on arterial
blood pressure and heart rate in the rat. Both GLP-1 (7–36) amide and exendin-4 produced
a dose-dependent increase in systolic, diastolic and mean arterial blood pressure, as well
as in heart rate, although the effect of exendin-4 was more prolonged. These data indicate a
longer functional half-life in vivo for exendin-4 as compared to GLP-1 (7–36) amide, which …