[HTML][HTML] Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform
H Liu, M Sugiura, VE Nava, LC Edsall, K Kono… - Journal of Biological …, 2000 - ASBMB
Sphingosine-1-phosphate (SPP) has diverse biological functions acting inside cells as a
second messenger to regulate proliferation and survival, and extracellularly, as a ligand for
G protein-coupled receptors of the endothelial differentiation gene-1 subfamily. Based on
sequence homology to murine and human sphingosine kinase-1 (SPHK1), which we
recently cloned (Kohama, T., Oliver, A., Edsall, L., Nagiec, MM, Dickson, R., and Spiegel,
S.(1998) J. Biol. Chem. 273, 23722–23728), we have now cloned a second type of mouse …
second messenger to regulate proliferation and survival, and extracellularly, as a ligand for
G protein-coupled receptors of the endothelial differentiation gene-1 subfamily. Based on
sequence homology to murine and human sphingosine kinase-1 (SPHK1), which we
recently cloned (Kohama, T., Oliver, A., Edsall, L., Nagiec, MM, Dickson, R., and Spiegel,
S.(1998) J. Biol. Chem. 273, 23722–23728), we have now cloned a second type of mouse …