[HTML][HTML] Association of the A-204C polymorphism in the cholesterol 7α-hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the …
P Couture, JD Otvos, LA Cupples, PWF Wilson… - Journal of lipid …, 1999 - ASBMB
The first reaction of the catabolic pathway of cholesterol is catalyzed by CYP7 and serves as
the rate-limiting step and major site of regulation of bile acid synthesis in the liver. A common
A to C substitution at position-204 of the promoter of CYP7 gene has been associated with
variations in plasma LDL-cholesterol concentrations but the effect of this polymorphism is
unknown in the general population. The aim of the present study was therefore to investigate
the association of this polymorphism to lipoprotein levels in a population-based sample of …
the rate-limiting step and major site of regulation of bile acid synthesis in the liver. A common
A to C substitution at position-204 of the promoter of CYP7 gene has been associated with
variations in plasma LDL-cholesterol concentrations but the effect of this polymorphism is
unknown in the general population. The aim of the present study was therefore to investigate
the association of this polymorphism to lipoprotein levels in a population-based sample of …