[CITATION][C] Selectins and their ligands: current concepts and controversies

GS Kansas - 1996 - ashpublications.org
GS Kansas
1996ashpublications.org
ITH THE ESSENTIALLY simultaneous cloning in 1989 of the selectins (then called ELAM-1,
GMP-140/PADGEM, and LECAM-1ILAM-1; now called E-selectin, P-selectin, and L-selectin
or CD62E, CD62P, and CD62L, respectively), and the recognition of a new family of cell
adhesion molecules critically involved in the regulation of leukocyte traffic, a new era
dawned in the study of leukocyte-endothelia1 recognition. Rapid progress has since been
made in understanding the molecular and cellular basis of selectin-mediated adhesion, the …
ITH THE ESSENTIALLY simultaneous cloning in 1989 of the selectins (then called ELAM-1, GMP-140/PADGEM, and LECAM-1ILAM-1; now called E-selectin, P-selectin, and L-selectin or CD62E, CD62P, and CD62L, respectively), and the recognition of a new family of cell adhesion molecules critically involved in the regulation of leukocyte traffic, a new era dawned in the study of leukocyte-endothelia1 recognition. Rapid progress has since been made in understanding the molecular and cellular basis of selectin-mediated adhesion, the identification of cellular ligands for selectins, the biophysics of selectins, and the physiologic role played by selectins in both normal leukocyte traffic and in a range of inflammatory and other diseases. This review will highlight this progress, and define some important questions for the future.
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